We call aging {Senescence}, when stressed cells can no longer divide into new cells and is considered a factor in certain diseases. Scientists have evidence that at a younger age, aging εμφαν Senescence} cells appear quickly after a major injury and are protective. According to Raghavan Pillai Raju, a biomedical researcher in the Department of Pharmacology and Toxicology MCG {author of the study} if cells immediately go into an aging state, they can help prevent organ failure. For a relatively new class of drugs that target aging cells for abortion, laboratory studies have shown that they can prevent or improve age-related problems such as weakness, cataracts, and vascular and heart failure.
Early human trials have reported success in reducing the progression of problems such as diabetes and kidney damage. But when younger rats with hemorrhagic shock were given the drugs as part of the fluids used for resuscitation shortly after the blood loss, they all died quickly. Experimental induction of acute aging may be a necessary procedure in hemorrhagic shock, where aging cell death appears aggravate tissue injury from blood loss. The rapid transition to aging that occurred in a liver cell population was an attempt at post-traumatic stabilization {possibly transient} is the first evidence that cellular aging can develop within a few hours of tissue injury following hemorrhagic injury.
Senescence’s aging of cells is known to be caused by cellular stress, such as DNA damage, oncogen activation, mitochondrial dysfunction and oxidative stress, an accumulation of reactive oxygen species that contributes to certain diseases {heart}. In fact, there is a link between significant injury and aging, where mitochondrial function is reduced in both. As we age, cells slowly stop dividing, expressing certain markers {secreting cytokines} and this state of cellular cessation of proliferation under pressure is aging. Senescence} aging is an important function throughout life that begins during growth, when endless decisions are made about which cells to maintain or eliminate, or at least calm down, and this continues throughout life as part of daily cellular activity.
Although, aging is a death sentence for cells, which begin to secrete acid small acid-soluble proteins} SASPs so that the cell can be labeled by immune cells κρο macrophages} for destruction, but it can also make the cells less vulnerable to programmed cell death or apoptosis. Apoptosis is suicidal versus homicide, and aging appears to allow cells to choose a lower-functioning state than death.
Elevated levels of SASPs or aging-related markers such as growth factors and enzymes that break down proteins and peptides, high levels of aging cells. SASPs can be both beneficial and harmful, causing problems such as insulin resistance and inflammation, but they also help with wound healing and tissue regeneration. Cell division is important for replacing high-turnover cells in areas such as the gut and skin, as well as for wound healing, but the rate slows with age. Apart from the fact that aging can prevent cells from rapidly dividing cancer cells, it is widely considered to be detrimental to aging health.
Scientists have found that aging is not always bad and can be good after injury where cells can even heal in this condition.
SOURCE: Medical College of Georgia {Aging Cell Sept. 2020}