Scientists disclosed a totally new molecular procedure (in mice), which activates inflammation caused by T cells and leads to different autoimmune diseases, (multiple sclerosis, arthritis, diabetes type 1, inflammation of the intestine etc.)
In the last decade the cytokine IL-1b of the immune system has been associated with various autoimmune diseases and drugs. The antibodies that inhibit or inhibit IL-1b are currently used in different types of autoimmune diseases.
It was previously considered that the production of IL-1b required the activation of a group of proteins of the immune system {The flamingbodies } that can cause self-inflammatory diseases, but are distinguished by autoimmune diseases. It was established that a different molecular pathway {The interaction of myeloid and CD4-positive T cells} causes inflammation, during autoimmunity, regardless of the Phlegmon. Unfortunately, in the case of autoimmunity, the immune system attacks and eventually destroys healthy tissues incorrectly targeted as harmful.
IL-1b Tan does not fulfill its role in causing autoimmunity{ It usually acts as an antimicrobial immunity stimulator} then the self-reactive T cells, macrophages and dendritics cells work through TNF and FASL and produce excessively large amounts of IL-1b. It is revealed that IL-1b may be caused by the absence of contamination with T cells being the main drivers of IL-1b in autoimmune regulation. Theself-reactive T cells have their own mechanisms to drive the inflammation and work independently of the Phlegmonomas.
Targeting TNF and Fasl {related to IL-1b production } is an effective way to deal with autoimmune diseases.
NOTE: Konstantinion Research Center has investigated 13 cytokines (IL-16, IFN-γ, IL-2, IL-10, IL-8, IL-6, IL-4, IL-5, IL-1b, TNF-a, IL-12, IL-17A, IL-23), and together with the immunology of cytokines can be in close collaboration with clinical doctors in Greece and abroad for the most effective daily clinical targeted therapy for most diseases. This is simply achieved by just drawing blood for a patient.
SOURCE: Cincinnati Children’s Hospital Medical Center{ December 2019}
