The infusion of intralipid based on an old protocol with 2 or 3 infusions of 250 ml (one before the embryotransfer or before the (PT) pregnancy test) and 3 infusions after a positive PT, which is administered by anesthesiologist or cardiologist is totally wrong and is not suitable for the successive inhibition of NK cells in reproductive immunology. Also, this dosage is way too much for a woman that wants to be pregnant, and doesn’t contribute to inhibition of NK cells, BUT leads to magnificent increase of NK cells (total and endometrial) and the results will be failed IVF or miscarriage of the embryo.
Conclusively, the administration of intralipid MUST be performed ONLY by specialists, which have the knowhow and experience in clinical and laboratorial issue of NK markers (total, endometrial NK, and activity of NK cells). Couples have to be careful because some labs show a series of CDs, where the claim that is the analysis of NK cells, and they confuse the public. It must be noted that these labs just test of reproductive immunophenotype, which is the subpopulation of lymphocytes.
Serious Side Effects
The administration of high dosage of intralipid (1 of 250ml) can cause a series of serious adverse effects has been reported: acute kidney injury, cardiac arrest, acute lung injury, venous thromboembolism, fat embolism, fat overload syndrome, pancreatitis, allergic reactions and increased susceptibility to infection (Hayes et al., 2016).
